Preparation
method for continuously separating sesamin and sesamolin from sesame includes the following steps:
(1) Sesame is used as raw material, and after ultra-fine grinding, ultrasonic-assisted reflux extraction is performed using a haloalkane solvent to obtain an extract containing sesamin and sesamolin;
(2) The extract is decolorized, concentrated, and the organic solvent is recovered to obtain a concentrated solution, which is adsorbed by macroporous adsorption resin, eluted with ethanol, and the eluent is collected;
(3) The eluent is concentrated, and the concentrated solution is separated using simulated moving bed chromatography to obtain sesamin and sesamolin from sesame with a purity of over 99.90%.
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from sesame.
Uses
Synergist for pyrethrum insecticides.
Definition
Con-
stituent of sesame oil that is a powerful syner-
gist of pyrethrum. A 1:1 mixture of pyrethrum and
sesamoline has 31 times the insecticidal activity of
pyrethrum alone.
Hazard
Moderately toxic by ingestion.
Biological Activity
It also exerts antimicrobial, anti-melanogenesis, and neuroprotective effects.', 'Sesamolin is reported to have beneficial physiological properties such as antioxidant, anti-mutagenic, anti-aging and anti-inflammatory activities. It was also found to inhibit lipid peroxidation in r at liver and kidney. Sesamolin enhances NK cell lysis activity by increasing the expression of NKG2D ligands on Burkittμs lymphoma cells, presenting a potential immunotherapeutic value for cancer treatment. In addition, it was demonstrated th at sesamolin inhibits β-secretase, presenting an important role for prevention of dementia by daily consumption.
