TYRPHOSTIN A1

Chemical Properties

light yellow crystalline needles or crystals

Uses

Tyrphostin A1 is an inactive Tyrphostin used as a negative control for Tyrphostin A23.

Definition

ChEBI: Tyrphostin 1 is a member of methoxybenzenes. It has a role as a geroprotector.

Synthesis Reference(s)

Synthetic Communications, 21, p. 1163, 1991 DOI: 10.1080/00397919108021035
Synthesis, p. 23, 1970

Biological Activity

Tyrphostin 1 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain. Tyrphostin 1 is also known to block EGF-dependent receptor autophosphorylation,. Furthermore, studies have reported th at tyrphostin 1 can block Ca2+ channels and inhibit growth in vascular smooth muscle cells,.', 'EGFR tyrosine kinase inhibitor.