Description
tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu is the 18-carbon fatty acid side chain of somatostatin, which contributes to an increased affinity for albumin (approximately 5-6 fold). Somalutide is a glucagon-like peptide-1 (GLP-1) analogue with hypoglycaemic properties.
Uses
(S)-22-(Tert-butoxycarbonyl)-10,19,24-trioxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontane-1,41-dioic acid can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and chemical production processes.
Definition
TBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu is also known as Semaglutide Side Chain. An 18-carbon fatty acid side chain of semaglutide. The affinity of the semaglutide side chain for albumin was enhanced 5-6 times. Semaglutide is a glucagon-like peptide-1 (GLP-1) analog with significant hypoglycemic efficacy.
Application
OLED intermediates, Pharmaceutical Raw Intermediates, Fine Chemical Intermediate
General Description
tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu, as the side chain
of semaglutide, can be used in the solid-phase and semi-synthetic
recombinant fermentation process of semaglutide.
References
[1] IVAN GURYANOV*. Copper(II) Lysinate and Pseudoproline Assistance in the Convergent Synthesis of the GLP-1 Receptor Agonists Liraglutide and Semaglutide[J]. Organic Process Research & Development, 2021, 25 7: 1598-1611. DOI:
10.1021/acs.oprd.1c00021[2] THOMAS B. KJELDSEN. Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320[J]. Journal of Medicinal Chemistry, 2020, 64 1: 616-628. DOI:
10.1021/acs.jmedchem.0c01576
