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tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu is the 18-carbon fatty acid side chain of somatostatin, which contributes to an increased affinity for albumin (approximately 5-6 fold). Somalutide is a glucagon-like peptide-1 (GLP-1) analogue with hypoglycaemic properties.

(S)-22-(Tert-butoxycarbonyl)-10,19,24-trioxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontane-1,41-dioic acid can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and chemical production processes.

OLED intermediates, Pharmaceutical Raw Intermediates, Fine Chemical Intermediate

TBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu is also known as Semaglutide Side Chain. An 18-carbon fatty acid side chain of semaglutide. The affinity of the semaglutide side chain for albumin was enhanced 5-6 times. Semaglutide is a glucagon-like peptide-1 (GLP-1) analog with significant hypoglycemic efficacy.

tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu, as the side chain of semaglutide, can be used in the solid-phase and semi-synthetic recombinant fermentation process of semaglutide.

[1] IVAN GURYANOV*. Copper(II) Lysinate and Pseudoproline Assistance in the Convergent Synthesis of the GLP-1 Receptor Agonists Liraglutide and Semaglutide[J]. Organic Process Research & Development, 2021, 25 7: 1598-1611. DOI: 10.1021/acs.oprd.1c00021
[2] THOMAS B. KJELDSEN. Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320[J]. Journal of Medicinal Chemistry, 2020, 64 1: 616-628. DOI: 10.1021/acs.jmedchem.0c01576