Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe

Uses

TRAP-14 (SFLLRNPNDKYEPF) is a synthetic thrombin receptor agonist peptide.

Biological Activity

Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe has contractile effects on vascular and gastric smooth muscle. It stimulates the hydrolysis of phosphoinositides.', 'Thrombin receptor activator

storage

Store at -20°C

References

[1] Sugama Y, et al. Thrombin receptor 14-amino acid peptide mediates endothelial hyperadhesivity and neutrophil adhesion by P-selectin-dependent mechanism. Circ Res. 1992 Oct;71(4):1015-9. DOI:10.1161/01.res.71.4.1015
[2] Sabo T, et al. Structure-activity studies of the thrombin receptor activating peptide. Biochem Biophys Res Commun. 1992 Oct 30;188(2):604-10. DOI:10.1016/0006-291x(92)91099-c
[3] Maruyama Y, et al. Thrombin receptor agonist peptide decreases thrombomodulin activity in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun. 1994 Mar 30;199(3):1262-9. DOI:10.1006/bbrc.1994.1367