Synthesis
The general procedure for the synthesis of 3-chlorobenzylamine from 3-chlorobenzonitrile was as follows: in a 25 mL round-bottomed flask, CuNP/WS catalyst was added to a mixed solution containing 5 mL of double-distilled water and 1 mmol of 3-chlorobenzonitrile. Subsequently, 4 mmol NaBH4 was added to the reaction mixture in 4 portions and stirred at room temperature for an appropriate time. The reaction process was monitored by thin layer chromatography (TLC) using ethyl acetate/hexane (1:5) as eluent. After completion of the reaction, the reaction mixture was filtered and the catalyst was rinsed twice with dichloromethane. The organic phase was washed with distilled water, dried over anhydrous MgSO4 and finally the solvent was evaporated under vacuum to give the target product 3-chlorobenzylamine.
References
[1] Journal of Organic Chemistry, 2012, vol. 77, # 1, p. 221 - 228
[2] ChemSusChem, 2017, vol. 10, # 5, p. 842 - 846
[3] Journal of the American Chemical Society, 2017, vol. 139, # 38, p. 13554 - 13561
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 19, p. 7965 - 7983
[5] Inorganic and Nano-Metal Chemistry, 2018, vol. 48, # 3, p. 176 - 181
