Anti-PHLPPL

Uses

Anti-PHLPP2 (N-term) antibody produced in rabbit has been used in immunoblotting.

General Description

The PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2) gene with 18 exons, is mapped to human chromosome 16q22.2. The encoded protein is a isoform of PHLPP family and is composed of 1323 amino acids. PHLPP2 is characterized with a pleckstrin homology domain (PH domain), leucine-rich repeats, a protein phosphatase 2C (PP2C) domain and a PDZ-binding motif.

Biochem/physiol Actions

PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2) is a tumor suppressor. It plays a vital role in cell survival by inactivating Akt, inhibiting cell-cycle progression and stimulating apoptosis. Expression of PHLPP protein is decreased in hypopharyngeal squamous cell carcinomas (HSCCs). Thus, this protein can be used as a marker to determine the poor prognosis in HSCCs patients.