4-Guanidinobutyl 4-hydroxy-3,5-diMethoxybenzoate hydrochloride

Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice^[1]. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice^[2]. Leonurine (20 mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model^[3].