Description
Methylophiopogonanone B (MO‑B), which belongs to a group of homoisoflavonoids, present in Ophiopogon japonicus, has been identified as an active component with antioxidative and anti‑tumor properties.
Chemical Properties
Methylophiopogonanone B is soluble in methanol, ethanol, DMSO and other organic solvents, and is derived from the fibrous root of Ophiopogon japonicus.
Uses
Methylophiopogonanone B has the effect of enhancing protease activity and regulating cytoskeleton remodeling.
Synthesis
Methylophiopogonanone B was synthesized from 2,4,6-trihydroxy-3,5-dimethylacetophenone in 57% yield.
References
[1] M. FUJII. First synthesis of racemic methylophiopogonanone B and its inhibitory activity of hypoxia-inducible factor-1α[J]. Heterocycles, 2009, 78 1: 207-212. DOI:
10.3987/COM-08-11517.
