Chemical Properties
rac Lafutidine is Off-White Solid
Uses
rac Lafutidine is a second generation histamine H2-receptor antagonist. Lafutidine is used as an antiulcerative.
Uses
Second generation histamine H2-receptor antagonist. Antiulcerative.
Definition
ChEBI: Lafutidine is an organic molecular entity.
in vivo
(Z)-Lafutidine (Compound 16) stimulates mucin biosynthesis in rat gastric mucosa and this effect not directly due to histamine H2 receptor antagonism[1].
| Animal Model: | Eight- to nine-week-old male C57BL/6 mice weighing 20-24g[1] |
| Dosage: | 3-30 mg/kg |
| Administration: | P.o; twice for 6 days (5-FU: 50 mg/kg; i.p.;once daily) |
| Result: | Reduced the severity of diarrhea during 5-FU treatment,in a mostly dose-dependent manner, and a significant effect was observed at a dose of 30 mg/kg.
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