Palmitoyl Tripeptide-5

Anti-aging Properties

Syn-Coll, or palmitoyl tripeptide-3/5 (Palmitoyl-lysyl-valyl-lysine bistrifluoracetate salt), is a synthetic signal oligopeptide that has been shown to promote collagen formation in both in vitro and in vivo studies through the growth factor TGFβ. The mechanism of this peptide is similar to thrombosponin I (TSPI) activity. TSPI is expressed in dermal cells, especially during wound healing. This protein binds to latent TGFβ and induces conformational change, increasing the production of collagen as a downstream effect. One study showed that treatment of TSPI null mouse wounds with the peptide KRFK was able to rescue the TSP1-dependent activation of TGFβ in dermal cells. Syn-Coll is a derivative of this sequence that has been coupled to a fatty acid moiety for increased permeation. In dermal fibroblast cells, the pharmacologic effects of a related peptide, KFK, is to increase collagen synthesis and downregulate MMP-1 expression through TGFβ. A controlled trial on 60 volunteers showed that Syn-Coll reduced skin roughness better than both placebo and Pal-KTTKS creams, when applied twice daily for 84 days.

Description

Palmitoyl tripeptide-5 is a cosmeceutical peptide.

Description

Palmitoyl tripeptide-5 is a synthetic peptide and consists of 3 chains of amino acids link together with fatty acids. Palmitoyl tripeptide can enter epidermis and can penetrate deep into the dermis, where it can help to stimulate collagen production and helps to grow healthy tissue growth.

Uses

Palmitoyl Tripeptide-5 is made up of chains of amino acids and can penetrate the epidermis and enter deep into the dermis, where may help to stimulate collagen production and healthy tissue growth.

Application

Palmitoyl Tripeptide-5 is a component of cell transduction, and promotes the production of collagen. It is commonly used in anti-aging and anti-wrinkle cosmetics.

Definition

Palmitoyl tripeptide-5 is a Thrombospondin I (TSP-1) fragment presenting the sequence N-(1-oxohexadecyl)-L-lysyl-L-valyl-L-lysine. Palmitoyl tripeptide-5 was used in a cosmetic ingredient mix from a raw material supplier, containing spent grain wax and conjugated linoleic acid (CLA), to reduce skin redness in type I rosacea. This peptide has been used in patented cosmetic formulations for sensitive skin. Palmitoyl tripeptide-5 is used in anti-aging cosmetic products due to its ability to reduce MMP'S, promote the synthesis of type I and type II collagen from extracellular matrix, and inhibit melanin production by reducing tyrosinase activity[1].

benefits

Palmitoyl Tripeptide-5 is super repairing multi-peptide, comprehensivelyimprove skin appearance due to aging from defenseto activation of cell of epidermis,basement membraneand corium layer, e.g.stretch marks, acne marks andscar due to laser, etc.Improve firmness, sofeness andelasticity of skin, long-lasting atin-aging. Winkeypatented product in China.Its recommended dosage is 1~5%.

Mechanism of action

Palmitoyl tripeptide-5 acts on the specific skin receptors and stimulates the production of collagen in our skin cells. It firms our skin, reduces the appearance of wrinkles and fine-lines. It makes your skin look healthier and fresh.Palmitoyl Tripeptide-5 also interact with hyaluronic acid and elastin production system. The combine effect is increased water content, reduce wrinkling of skin and enhance the firmness of skin.

Safety

Palmitoyl Tripeptide-5 is a new ingredient and there are few researchers on it. But according to skincare specialist, Palmitoyl Tripeptide-5 is safe to use on any skin. It can’t react to your skin. There are no reported issue of any toxicity, allergy, sensitivity and hormone disruption. If you have a sensitive skin, you may react to anti-aging creams. You common skin reactions are redness, itching, stinging at the site of application.

References

[1] Resende, Diana I. S. P, et al. "Usage of Synthetic Peptides in Cosmetics for Sensitive Skin." Pharmaceuticals (Basel) (2021).