ANTIBIOTIC UCN-02

Description

UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01 first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. UCN-02 inhibits protein kinase C with a slightly reduced potency than UCN-01 (IC₅₀ = 62 and 4.1 nM, for UNC-02 and UCN-01, respectively) and is cytotoxic to the growth of HeLa S3 cells.

Uses

UCN-02 is an antibiotic and an indolocarbazole isolated from a high staurosporine-producing?Streptomyces?culture. Related analogs of staurosporine which is non-specific protein kinase inhibitor.

Uses

UCN-02 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms.

References

[1] takahashi, i. ,saitoh, y.,yoshida, m., et al. ucn-01 and ucn-02, new selective inhibitors of protein kinase c. ii. purification, physico-chemical properties, structural determination and biological activities. j.antibiot.(tokyo) 42(4), 571-576 (1989).
[2] newton a c. protein kinase c: structure, function, and regulation[j]. journal of biological chemistry, 1995, 270(48): 28495-28498.