ChemicalBook CAS DataBase List 5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide

5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide

Product Name5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide
CAS868273-06-7
CBNumberCB42092872
MFC24H28ClN3O
MW409.95
EINECS278-169-7
MDL NumberMFCD11045300
MOL File868273-06-7.mol
MSDS FileSDS

Chemical Properties

Boiling point	660.3±55.0 °C(Predicted)
Density	1.218±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H2O: <2mg/mL
form	powder
pka	14.87±0.30(Predicted)
color	white
FDA UNII	7YW2S3Z2CB

Safety

Hazard Codes	Xn
Risk Statements	22
WGK Germany	3

5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide Price

Product number	Packaging	Price	Product description	Buy
Usbiological 256120	10mg	$438	Org 27569 Asreported	Buy
Usbiological 256120	50mg	$1160	Org 27569 Asreported	Buy
Biosynth TJB27306	50mg	$828.5	Org 27569	Buy
Biosynth TJB27306	100mg	$1325	Org 27569	Buy
ChemScene CS-0514	5mg	$68	Org 27569 99.75%	Buy

5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide Chemical Properties,Usage,Production

Uses

Org 27569 is a drug that is a used in biological studies for structure-activity relationships of indole-carboxamides as CB1 receptor allosteric modulators.

Biological Activity

Potent CB 1 receptor allosteric modulator (pEC 50 = 8.24). Significantly increases binding of the CB 1 agonist [ 3 H]CP 55.940 (pK b = 5.67) and decreases binding of the CB 1 inverse agonist [ 3 H]SR 141716A (pK b = 5.95). Inhibits CB 1 receptor antagonist efficacy in vitro (pK b = 7.57).

in vivo

ORG 27569 (3.2 and 5.6 mg/kg, i.p.) significantly attenuates cocaine associated cue-induced reinstatement, cocaine priming-induced reinstatement, methamphetamine associated cue-induced reinstatement and methamphetamine priming-induced reinstatement in rat^[1]. Org27569 (30 mg/kg, i.p.) produces CB1-independent hypophagic effects and does not affect the discriminative stimulus effects of anandamide (AEA). Org27569 (100 μg intracerebroventricularly) does not affect the pharmacologic effects of systemically administered CP55,940 compared with vehicle^[3].

storage

Store at RT

References

[1] price mr1, baillie gl, thomas a, stevenson la, easson m, goodwin r, mclean a, mcintosh l, goodwin g, walker g, westwood p, marrs j, thomson f, cowley p, christopoulos a, pertwee rg, ross ra. allosteric modulation of the cannabinoid cb1 receptor. mol pharmacol. 2005 nov;68(5):1484-95. epub 2005 aug 19.
[2] fay jf1, farrens dl. a key agonist-induced conformational change in the cannabinoid receptor cb1 is blocked by the allosteric ligand org 27569. j biol chem. 2012 sep 28;287(40):33873-82. epub 2012 jul 30.

Preparation Products And Raw materials

5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
QINGDAO CARELONGPHARMATECH CO.,LTD	053288191853 13061484198	sales@carelongchem.com	China	457	57
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4765	58
NCE Biomedical Co.,Ltd.	4000-027-021 \|24 +86-13986109188 \| +86-15623472865 \| +81-08033611988		China	1490	55
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29975	65
AdooQ Bioscience CHINA	025-58849295	info@adooq.cn	China	2981	60
Hubei Jusheng Technology Co.,Ltd	027-59599241 18871490274	1400878000@qq.com	China	9491	58

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5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide Spectrum

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