Description
Isoxanthohumol is a natural, prenylated chalcone isolated from the hop plant,
H. lupulus (hops). It has diverse biological activities, including antiproliferative, anti-inflammatory, and antiviral properties. In B16 and A375 melanoma cells, isoxanthohumol inhibits proliferation (IC
50s = 22.15 and 22.9 μM in an MTT assay), slows cell division, and induces apoptosis. Isoxanthohumol reversibly inhibits K
v1.3 channels with an EC
50 value of 7.8 μM in human Jurkat T cells using patch clamp electrophysiology. It has strong deterrent properties against the peach potato aphid. It has also been used as a marker of beer consumption. Isoxanthohumol is metabolized in the liver and intestine to 8-prenylnaringenin , a potent phytoestrogen.
Uses
Isoxanthohumol is a prenylated flavone isolated from hop. A chromane-like cyclic prenylflavonoids for neurological disorder therapy. Isoxanthohumol is a prenylated flavonoid phytoestrogen which is an apoptosis inducer in mature adipocytes
Definition
ChEBI: Isoxanthohumol is a member of flavanones.
References
[1] ANNA KATARZYNA ONIERCZYK. Isoxanthohumol — Biologically active hop flavonoid[J]. Fitoterapia, 2015, 103: Pages 71-82. DOI:
10.1016/j.fitote.2015.03.007[2] TAMARA KRAJNOVI . Versatile antitumor potential of isoxanthohumol: Enhancement of paclitaxel activity in vivo[J]. Pharmacological research, 2016, 105: Pages 62-73. DOI:
10.1016/j.phrs.2016.01.011[3] JUSTYNA GSIOROWSKA. Inhibition of Kv1.3 Channels in Human Jurkat T Cells by Xanthohumol and Isoxanthohumol.[J]. Journal of Membrane Biology, 2015, 248 4: 705-711. DOI:
10.1007/s00232-015-9782-0[4] PAOLA QUIFER-RADA . Urinary Isoxanthohumol Is a Specific and Accurate Biomarker of Beer Consumptionce1, 2, 3[J]. Journal of Nutrition, 2014, 144 4: Pages 484-488. DOI:
10.3945/jn.113.185199
