Isoxanthohumol is a natural, prenylated chalcone isolated from the hop plant,
H. lupulus (hops). It has diverse biological activities, including antiproliferative, anti-inflammatory, and antiviral properties.
1 In B16 and A375 melanoma cells, isoxanthohumol inhibits proliferation (IC
50s = 22.15 and 22.9 μM in an MTT assay), slows cell division, and induces apoptosis.
2 Isoxanthohumol reversibly inhibits K
v1.3 channels with an EC
50 value of 7.8 μM in human Jurkat T cells using patch clamp electrophysiology.
3 It has strong deterrent properties against the peach potato aphid.
4 It has also been used as a marker of beer consumption.
5 Isoxanthohumol is metabolized in the liver and intestine to 8-prenylnaringenin (Item No.
17462), a potent phytoestrogen.
5 
