Description
Marcfortine A is an indole alkaloid originally isolated from
P. roqueforti. It has nematocidal activity against the parasitic nematode
H. contortus (LD
99 = 0.06 μg/ml) and inhibits motility of adult worms (EC
50 = 2 μM)., Marcfortine A eliminates
H. contortus,
T. colubriformis, and
O. ostertagi from experimentally infected jirds (ED
95s = 0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α
3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.
Uses
Marcfortine A is an indole alkaloid isolated from Aspergillus and Pencillium species.
Uses
Marcfortine A is an indole alkaloid, isolated from Aspergillus and Pencillium species, with potent nematocidal activity. The marcfortines are structurally related to paraherquamides and are thought to act by blocking cholinergic neuromuscular transmission.
References
[1] J. POLONSKY. Isolation and structure (X-ray analysis) of marcfortine A, a new alkaloid from Penicillium roqueforti[J]. Journal of The Chemical Society, Chemical Communications, 1980, 278 1: 601-602. DOI:
10.1039/c39800000601[2] ROBERT J. CAPON. Aspergillicins A—E: Five Novel Depsipeptides from the Marine-Derived Fungus Aspergillus carneus.[J]. ChemInform, 2003, 34 40. DOI:
10.1002/chin.200340185[3] S S JOHNSON. Interrelationships among physicochemical properties, absorption and anthelmintic activities of 2-desoxoparaherquamide and selected analogs.[J]. Journal of veterinary pharmacology and therapeutics, 2004, 27 3: 169-181. DOI:
10.1111/j.1365-2885.2004.00577.x[4] ZINSER E W, Mark L. Wolf, Susan J. Alexander-Bowman, et al. Anthelmintic paraherquamides are cholinergic antagonists in gastrointestinal nematodes and mammals[J]. Journal of veterinary pharmacology and therapeutics, 2002, 25 4: 241-250. DOI:
10.1046/j.1365-2885.2002.00423.x
