Description
16-
phenyl tetranor PGE
2 is a metabolically stable synthetic analog of PGE
2. 16-
phenyl tetranor PGE
2 is five times more potent than PGE
2 in causing hypotension in dogs (0.1 μg/kg dose).
1 It is comparable to PGE
2 in inhibiting histamine-
induced bronchoconstriction in conscious guinea pigs.
1
Definition
ChEBI: 16-Phenyl-tetranor-PGE2 is a prostanoid.
References
1. Johnson, M.R., Schaaf, T.K., Constantine, J.W., et al.
Structure activity studies leading to a tissue-selective hypotensive prostaglandin analog, 13,14-dihydro-16-phenyl-ω-tetranor PGE2 Prostaglandins 20(3),515-520(1980).