Policresulen

Description

Policresulen is a potent inhibitor of DENV2 NS2B/NS3 protease that inhibits DENV2 replication in BHK-21 cells. The binding mode of the protease and policresulen provides useful hints for designing new type of inhibitors against the protease.

Uses

Policresulen is a potent novel NS2B/NS3 inhibitor and effectively inhibits the replication of DEV2 virus (dengue virus) in BHK-21 cells.

Uses

Policresulen is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:Hemorrhoids,Gynecological infections,Inflammations of tissues,Policresulen may also be used for purposes not listed here.

Biological Activity

Policresulen promotes selective chemical debridement: being an anion, it has the ability to interact only with the phospholipid molecules of the plasma membranes of to devitalized cells, which have lost its original electric charge. This contact provides the denaturation of cellular proteins, facilitating their removal. Its acidity, together with coagulating properties, give policresulen antimicrobial activity against staphylococcus spp., streptococcus spp. and Candida albicans. Policresulen is often used for gynecological infections. It is also used to treat canker sore in some countries.

Clinical Use

Policresulen is a topical hemostatic and antiseptic indicated for common anal disorders, such as hemorrhoids, and for gynecological infections. Policresulen has hemostatic activity by causing coagulation of blood proteins and promoting the contraction of the muscular fibers of the blood vessels of small caliber.

Side effects

The following is a list of possible side-effects that may occur in medicines that contain Policresulen. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.Feeling of a foreign body in the uterus;Discomfort in the lower abdomen;Vaginal irritation;Vaginal dryness and allergic reactions;Policresulen may also cause side-effects not listed here.