Description
Escin, monosodium salt is a natural product obtained from the plant horse chestnut. It is used in the treatment of chronic venous insufficiency, where it has been shown to have anti-inflammatory and anti-thrombotic effects. It is a mixture of polysulphated disaccharides that can be purified by HPLC.
Chemical Properties
Sodium saponin salt obtained from the extract of the dried mature fruit (Solanum serrata) of the Castanea plant.
Uses
Monosodium salt of Escin (E658790), has been used as a treatment for ischemic damage, hemorrhoids, and trauma or for recovery post-operation. Also used in the treatment of adenocarcinoma cell lines.
Safety Profile
Poison by ingestion,
intravenous, intraperitoneal, and
subcutaneous routes. Experimental
teratogenic and reproductive effects. When
heated to decomposition it emits toxic
fumes of Na2O. See also SAPONIN and
other escin entries.
in vivo
Sodium aescinate may effectively controls and improves wound healing in diabetic rats via its anti-inflammatory and antioxidant activities[1].
Sodium aescinate treatment can alleviate the symptom of polycystic ovary syndrome (PCOS) in rat model through regulating the PI3K/Akt/GSK3-β pathway[4].
target
NO | TNF-α | IL Receptor | Bcl-2/Bax | VEGFR
