ChemicalBook CAS DataBase List 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride

6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride

Product Name6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride
CAS56776-32-0
CBNumberCB3883790
MFC17H18Cl2N2O
MW337.24362
EINECS260-380-0
MDL NumberMFCD18086857
MOL File56776-32-0.mol
MSDS FileSDS

Chemical Properties

Melting point	ND
storage temp.	-20°C
solubility	DMSO: ≥5mg/mL
form	powder
color	white to beige
Stability	Hygroscopic
InChI	1S/C17H17ClN2O.ClH/c1-3-19-16-20-15-10-9-13(18)11-14(15)17(2,21-16)12-7-5-4-6-8-12;/h4-11H,3H2,1-2H3,(H,19,20);1H
InChIKey	SCBJXEBIMVRTJE-UHFFFAOYSA-N
SMILES	Cl.CCNC1=Nc2ccc(Cl)cc2C(C)(O1)c3ccccc3
FDA UNII	NBL8010WH5
UNSPSC Code	12352200
NACRES	NA.77

Safety

Symbol(GHS)
Signal word	Danger
Hazard statements	H302-H318
Precautionary statements	P264-P270-P301+P312-P330-P501-P280-P305+P351+P338-P310
Hazard Codes	Xn
Risk Statements	22
WGK Germany	3
Storage Class	11 - Combustible Solids

6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride Price

Product number	Packaging	Price	Product description	Buy
Sigma-Aldrich SML0272	10mg	$182	Etifoxine hydrochloride ≥98% (HPLC)	Buy
Sigma-Aldrich SML0272	50mg	$696	Etifoxine hydrochloride ≥98% (HPLC)	Buy
Axon Medchem Axon3331	10mg	$121	Etifoxine hydrochloride	Buy
Axon Medchem Axon3331	50mg	$484	Etifoxine hydrochloride	Buy
ApexBio Technology A3401	10mg	$112	Etifoxine hydrochloride	Buy

6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride Chemical Properties,Usage,Production

Chemical Properties

Low Melting White Solid

Uses

Psychotropic agent with anxiolytic and anticonvulsant activity.

Uses

Etifoxine hydrochloride has been used as a γ-aminobutyric acid (GABA)-receptor agonist to study its effects on insulin expression in α cell line (αTC1)

Biochem/physiol Actions

Etifoxine is an anxiolytic anticonvulsant, which promotes axonal regeneration. It binds to β2 and β3 subunits of the GABAA receptor complex, a different target site to benzodiazepines, and binds to the translocator protein (18 kDa) TSPO, formerly known as the peripheral or mitochondrial benzodiazepine receptor. TSPO carries cholesterol from the outer to the inner mitochondrial membrane, which is the rate-limiting step of steroidogenesis. Whereas, its anxiolytic effects involve GABAA receptors and TSPO, etifoxine′s neuroregenerative effects mainly involve TSPO.

in vivo

Etifoxine competitively inhibits [³⁵S]TBPS binding with micromolar potency in rat brain^[1].
Etifoxine (3.125-50 mg/kg) exhibits more pronounced anxiolytic and anticonvulsant effects in the BALB/cByJ mice compared to the C57BL/6J mice^[3].

Animal Model:	Six-week old BALB/cByJ and C57BL/6J mice (20-25 g)^[3].
Dosage:	3.125-50 mg/kg.
Administration:	Intraperitoneal inhection.
Result:	Significantly increased the amount of time spent on the open arms at the 12.5 mg/kg dose when compared to vehicle (p = 0.009) in BALB/cByJ mice but produced no effect in C57B/6J mice. BALB/cByJ mice compared with C57BL/6J mice exhibited significantly (p < 0.012) lower plasma levels of the compound at 15 and 30 min.

storage

Store at +4°C

Preparation Products And Raw materials

6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30225	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15074	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9539	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49968	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43333	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58

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