Uses
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc[1][2].
References
[1] Subedi A, et al. Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening. Biochem Biophys Res Commun. 2016 Jun 3;474(3):528-533. DOI:
10.1016/j.bbrc.2016.04.124[2] Liu C, et al. Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1. Mol Med Rep. 2017 May;15(5):3210-3214. DOI:
10.3892/mmr.2017.6399
