Description
Iloprost is a second generation structural analog of prostacyclin (PGI
2) with about ten-
fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP receptors with a K
i of 11 nM. 15(R)-
Iloprost is the “unnatural” or inverted C-
15 epimer of iloprost. This transformation frequently attenuates the biological agonist activity of prostaglandin analogs by several orders of magnitude. There are no literature reports of the biological activity of 15(R)-
iloprost.
