Description
Clindamycin palmitate is a water-soluble prodrug form of the antibiotic clindamycin . It undergoes rapid hydrolysis
in vivo to release active clindamycin. Formulations containing clindamycin palmitate have been used in the treatment of various bacterial infections.
Chemical Properties
White Solid
Uses
antibacterial (tuberculostatic)
Uses
Clindamycin Palmitate is a semi-synthetic antibiotic with high bioavailability. Clindamycin Palmitate is an antibacterial.
Definition
ChEBI: Clindamycin palmitate hydrochloride is a S-glycosyl compound.
brand name
Cleocin (Pharmacia & Upjohn).
General Description
Clindamycin palmitate hydrochloride (Cleocin Pediatric) isthe hydrochloride salt of the palmitic acid ester ofcleomycin. The ester bond is to the 2-hydroxyl group of thelincosamine sugar. The ester serves as a tasteless prodrugform of the antibiotic, which hydrolyzes to clindamycin inthe plasma. The salt form confers water solubility to theester, which is available as granules for reconstitution intoan oral solution for pediatric use. Although absorption of thepalmitate is slower than that of the free base, there is littledifference in overall bioavailability of the two preparations.Reconstituted solutions of the palmitate hydrochloride arestable for 2 weeks at room temperature. Such solutionsshould not be refrigerated because thickening occurs thatmakes the preparation difficult to pour.
References
[1] CH. BHARATHI . Identification, isolation and characterization of impurities of clindamycin palmitate hydrochloride[J]. Journal of pharmaceutical and biomedical analysis, 2008, 48 4: Pages 1211-1218. DOI:
10.1016/j.jpba.2008.08.011
