Pancuronium (bromide hydrate)

Description

Pancuronium is an aminosteroid antagonist of muscle-type nicotinic acetylcholine receptors (nAChRs) with an IC₅₀ value of 14.8 nM using patch clamp electrophysiology in BOSC23 cells expressing mouse nAChRs. It acts as a non-depolarizing neuromuscular blocking agent. Pancuronium enhances anesthesia induced by isoflurane , reducing immobilization with an ED₅₀ value of 1.62 μg/kg.