Temocapril (10 mg/kg; p.o.; 21 d) enhances cardiomyocyte thioredoxin expression and ameliorates autoimmune myocarditis[3].
Temocapril (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney[4].
| Animal Model: | Experimental autoimmune myocarditis (EAM) rat model[3] |
| Dosage: | 10 mg/kg |
| Administration: | Oral gavage; administration by water; 21 days |
| Result: | Ameliorated EAM and prevented cellular proteins from oxidation.
Enhanced cardiomyocyte redox regulatory protein TRX expression.
|
| Animal Model: | Male Sprague Dawley rats[4] |
| Dosage: | 30 mg/kg |
| Administration: | Oral gavage, daily, for 4 weeks |
| Result: | Suppressed the blood pressure elevation induced by Ang I.
|