Chemical Properties
Clear colorless to slightly yellow liquid
Uses
N,N,N'',N'',N'''',N''''-Hexamethylmethanetriamine, can be used in the synthesis of the phosphoramidite derivative of the new nucleoside analog. It can also be used as reagent for the introduction of the dimethylaminoethylidene group.
Uses
Reagent for the introduction of the dimethylaminoethylidene group.1 General review;2 RO polymerization of lactide.3
Uses
Tris(dimethylamino)methane was used:
- to prepare the phosphoramidite derivative of the new nucleoside analog
- as reagent for the introduction of the dimethylaminoethylidene group
- in ring-opening (RO) polymerization of lactide
General Description
NMR spectra and their temperature-dependence has been reported for
tris(dimethylamino)methane.
Tris(dimethylamino)methane reacts with crowded α-(
o-nitrophenyl) ketone to yield tetrahydroquinoline derivative.
Purification Methods
Dry it over KOH and distil it through a Vigreux column (p 11) at water pump vacuum. Store it in the absence of CO2. [Bredereck et al. Chem Ber 101 1885 1968 and Angew Chem, Int Ed Engl 5 132 1966.]
