Description
VU0029251 is a partial antagonist of metabotropic glutamate receptor 5 (mGluR5; K
i = 1.07 μM).
1 It inhibits calcium mobilization induced by glutamate in HEK293 cell membranes expressing rat mGluR5 (IC
50 = 1.7 μM).
References
1. Rodriguez, A.L., Grier, M.D., Jones, C.K., et al.
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity Mol. Pharmacol. 78(6),1105-1123(2010).