330819-85-7

Name	3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine
CAS	330819-85-7
Molecular Formula	C10H11N3S2
Molecular Weight	237.34
MOL File	330819-85-7.mol

Synonyms

3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine 5H-Cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine, 6,7-dihydro-2-(methylthio)-

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Chemical Properties

storage temp.	Store at -20°C
solubility	DMF: 30mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2mg/mL; DMSO: 20mg/mL; PBS (pH 7.2): insolube
form	A crystalline solid

Hazard Information

Description

VU0029251 is a partial antagonist of metabotropic glutamate receptor 5 (mGluR5; K_i = 1.07 μM).¹ It inhibits calcium mobilization induced by glutamate in HEK293 cell membranes expressing rat mGluR5 (IC₅₀ = 1.7 μM).

Uses

VU0029251 is a mGluR5 partial antagonist (Ki: 1.07 μM). VU0029251 inhibits glutamate induced calcium mobilization in HEK293 cell membranes expressing rat mGluR5 (IC50: 1.7 μM)[1].

storage

Store at -20°C

References

1. Rodriguez, A.L., Grier, M.D., Jones, C.K., et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity Mol. Pharmacol. 78(6),1105-1123(2010).

Supplier

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Shanghai Hongye Biotechnology Co. Ltd

Telephone400-9205774

Websitehttp://www.glpbio.cn/

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Telephone 18818260767

Websitehttp://www.chemegen.com

TargetMol Chemicals Inc.

Telephone 4008200310

Websitehttps://www.targetmol.cn/

Cayman Chemical Company

Telephone800-364-9897

Websitehttp://www.caymanchem.com

Biosynth Biological Technology (Suzhou) Co Ltd

Telephone 51288865780

Websitehttp://www.biosynth.com

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