PJ-34
- Product NamePJ-34
- CAS344458-19-1
- CBNumberCB3434387
- MFC17H17N3O2
- MW295.34
- EINECS604-604-1
- MDL NumberMFCD17014689
- MOL FileMol file
- MSDS FileSDS
Chemical Properties
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | Soluble in DMSO |
FDA UNII | NA92ZAR7N2 |
PJ-34 Chemical Properties,Usage,Production
Definition
ChEBI: PJ34 is a member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor, an antiatherosclerotic agent, a cardioprotective agent, an anti-inflammatory agent and a neuroprotective agent. It is a member of phenanthridines, a secondary carboxamide and a tertiary amino compound. It is a conjugate base of a PJ34(1+).Enzyme inhibitor
This PARP inhibitor (FWfree-base = 295.34 g/mol; FWhydrochloride = 331.80 g/mol), systematically named N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)- N,N-dimethylacetamide and known for its activity in neuroprotection under stress conditions, exclusively eradicates multi-centrosomal human mammary, colon, lung, pancreas, ovarian cancer cells, by acting as an extracentrosome extracentrosome( s) de-clustering agent in mitosis. When applied at 20-30 μM, PJ-34 caused G2/M-arrest and a massive cell death Normal human proliferating endothelial, epithelial and mesenchymal cells were unaffected. PJ-34’s cytotoxicity on cancer cells is not attributable to PARP inhibition alone. PJ-34 was originally designed to protect neuronal cells in the central nervous system from cell death evoked by high activity of PARP-1 in response to DNA damage caused by brain injury, stroke or inflammation. Targets: extra-centrosome de-clustering; polyADP-ribose polymerase-1, EC50 = 20 nMPreparation Products And Raw materials
PJ-34 Supplier
Global(66)Suppliers
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008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9346 | 55 | |
0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 | |
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+1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 | |
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571-89925085 | sales@amadischem.com | China | 131981 | 58 | |
sales@boylechem.com | China | 2923 | 55 |
PJ-34 Spectrum
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