6-Bromo-3-iodo (1H)indazole

Application

A new and efficient Pd/C mediated method for C-3 alkynylation of 1H indazoles. 6-Bromo-3-iodo-1H-indazole was coupled with terminal alkynes in presence of Pd/ C-CuI-PPh3 catalytic system in ethanol solvent at 70°C to afford C-3 alkynylated products and/or C-3/C-6 dialkynylated products with good to excellent yields.¹

References

[1] Ghosh, S., Mondal, S., &amp; Hajra, A. (2020). Direct Catalytic Functionalization of Indazole Derivatives. <i>Advanced Synthesis &amp;amp; Catalysis, 362 18, Pages 3768-3794. https://doi.org/10.1002/adsc.202000423