Chemical Properties
light yellow oily liquid
Chemical Properties
N-Nitrosopiperidine is a clear, yellow, oily
liquid.
Uses
A carcinogenic nitrosocompound.
Definition
ChEBI: N-nitrosopiperidine is a nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite. It has a role as a carcinogenic agent, an apoptosis inducer, a mutagen and an environmental contaminant. It is a nitrosamine and a piperidine.
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 36, p. 459, 1988
DOI: 10.1248/cpb.36.459
General Description
Light yellow oil or liquid. May be a carcinogen.
Air & Water Reactions
Water soluble.
Reactivity Profile
N-NITROSOPIPERIDINE may react with strong oxidizing agents, especially peroxyacids. .
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition N-NITROSOPIPERIDINE emits highly toxic fumes.
Fire Hazard
Flash point data are not available for N-NITROSOPIPERIDINE, but N-NITROSOPIPERIDINE is probably combustible.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, and tumorigenic data. Poison
by ingestion, intravenous, and subcutaneous
routes. An experimental teratogen. Human
mutation data reported. When heated to
decomposition it emits toxic fumes of NOx.
See also N-NITROSO COMPOUNDS.
Potential Exposure
N-Nitrosopiperidine is found in some
foods and tobacco smoke. Used as a research chemical.
Carcinogenicity
N-Nitrosopiperidine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name
Required. UN3082 Environmentally hazardous substances,
liquid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous
material, Technical Name Required
Incompatibilities
Nitrated organics range from slight to
strong oxidizing agents. If mixed with reducing agents,
including hydrides, sulfides and nitrides, they may begin a
vigorous reaction. Reaction with aliphatic amines can
release carcinogenic nitrosamines. Incompatible with oxidizers
(chlorates, nitrates, peroxides, permanganates, perchlorates,
chlorine, bromine, fluorine, etc.); contact may cause
fires or explosions. Keep away from alkaline materials,
strong bases, strong acids, oxoacids, epoxides. Light and
UV may cause decomposition
Waste Disposal
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations governing
storage, transportation, treatment, and waste disposal.
Under 40 CFR 261.5 small quantity generators of this
waste may qualify for partial exclusion from hazardous
waste regulations.
