Description
Ceftriaxone is a third-generation, broad-spectrum cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It has been shown to increase excitatory amino acid transporter-2 pump expression in the central nervous system and to reduce glutamatergic toxicity in both
in vitro and
in vivo models.
Chemical Properties
White Crystalline Solid
Uses
An antibacterial, a third-generation cephalosporin.
Uses
A potentially useful antibacterial agent for proteomics research.
Definition
ChEBI: Ceftriaxone disodium salt hemiheptahydrate is a cephalosporin.
brand name
Rocephin (Roche).
Biological Activity
β -lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.
