Uses
3,5-Dimethoxybenzyl bromide may be used in various organic synthesis such as 3,4,3′,5′-tetramethoxystilbene; 3,5-dimethoxyphenylacetic acid; 1-(3,5-dimethoxyphenyl)-4-pentene etc., and 3,5-Dimethoxybenzyl bromide may be used as starting material in the multi-step synthesis of resveratroland 3,5-dimethoxyhomophthalic acid.
Chemical Properties
3,5-DIMETHOXYBENZYL BROMIDE is White Solid
Uses
3,5-DIMETHOXYBENZYL BROMIDE is used in dimethoxybenzene alkyl addition.
Uses
3,5-Dimethoxybenzyl bromide may be used in the synthesis of:
- 3,4,3′,5′-tetramethoxystilbene
- 3,5-dimethoxyphenylacetic acid
- 1-(3,5-dimethoxyphenyl)-4-pentene
It may be used as starting material in the multi-step synthesis of resveratrol and 3,5-dimethoxyhomophthalic acid.
General Description
3,5-Dimethoxybenzyl bromide is an aromatic bromide.
Synthesis
General procedure for the synthesis of 3,5-dimethoxybenzyl bromide from 3,5-dimethoxybenzyl alcohol: 3,5-dimethoxybenzyl alcohol (1 mmol) was dissolved in anhydrous benzene (15 mL) under anhydrous conditions and phosphorus tribromide (0.5 mL) was added. The reaction mixture was stirred at room temperature until the reaction was complete. The target product 3,5-dimethoxybenzyl bromide was obtained in quantitative yield by conventional post-treatment.
References
[1] Journal of Steroid Biochemistry and Molecular Biology, 2013, vol. 137, p. 332 - 344
[2] Journal of Asian Natural Products Research, 2011, vol. 13, # 4, p. 290 - 296
[3] Patent: WO2016/164703, 2016, A1. Location in patent: Page/Page column 41
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 24, p. 7683 - 7687
[5] Medicinal Chemistry Research, 2016, vol. 25, # 4, p. 627 - 643
