Uses
Hormone (adrenocorticotropic).
brand name
Acthar Gel-Synthetic (Armour).
General Description
Adrenocorticotropic hormone (ACTH) is a 303-amino acid hormone protein, which is located at human chromosome 2p23.3.
Biochem/physiol Actions
Adrenocorticotropic hormone (ACTH) stimulates melanocortin receptor (MC1R to MC5R).It is implicated in the production of α-melanocyte-stimulating hormone (α-MSH). Hypomethylation of ACTH promoter region in thymic carcinoids is associated with ectopic adrenocorticotropic hormone syndrome. Mutations in this gene are associated with aberrant fusion protein and impairing melanocortin signaling in hypoadrenalism. Dysregulation of ACTH leads to Cushing disease.
