Description
Xanthone is a compound that has been shown to have a significant cytotoxicity against HL-60 cells and to inhibit the cyclase enzyme. It also inhibits the protein production of mcl-1, which is necessary for the development of cancer cells.
Chemical Properties
off-white powder
Uses
Xanthone is used predominantly as oxygenated polycyclic aromatic compounds, and as a vasorelaxant. It can be used as a fluorescent agent, as well as an intermediate in organic synthesis and chemical research.
Uses
Acts as an inhibitor of human cancer cell lines.
Definition
A colorless crystalline organic compound found as a pigment in
gentians and other flowers. It is used as an
insecticide and in making dyestuffs.
Application
Xanthone has antiinflammatory activity and can be used in treating infectious diseases such as tuberculosis, malaria, and leprosy. The biological properties of it are shown by its ability to scavenge anion radicals and to act as a fluorescence probe for coumarin derivatives.
Definition
ChEBI: The parent compound of the xanthone class consisting of xanthene bearing a single oxo substituent at position 9.
Synthesis Reference(s)
The Journal of Organic Chemistry, 37, p. 4204, 1972
DOI: 10.1021/jo00798a059
Purification Methods
It has also been recrystallised from n-hexane three times and sublimed in vacuo. [Saltiel J Am Chem Soc 108 2674 1986]. [Beilstein 17 H 354, 17 I 190, 17 II 378, 17 III/IV 5292, 17/10 V 430.]
