BisindolylMaleiMide XI Hydrochloride

Uses

Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic inflammatory responses in vivo.

Biological Activity

Cell permeable: yes', 'Primary Target
PKCα', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 9 nM, 28 nM, 108 nM, against PKCα, PKCβI, and PKCε, respectively

in vivo

IC 50

PKC-α: 9 nM (IC₅₀); PKC-βI: 28 nM (IC₅₀); PKC-βII: 31 nM (IC₅₀); PKC-γ: 37 nM (IC₅₀); PKC-ε: 108 nM (IC₅₀)

storage

-20°C