BenzaMide, 4-fluoro-N-[3-(1-Methyl-4-piperidinyl)-1H-indol-5-yl]-, Monohydrochloride

Description

LY334370 is an agonist of the serotonin (5-HT) receptor subtype 5-HT_1F (K_d = 0.446 nM). It is selective for 5-HT_1F over other G protein-coupled 5-HT receptor subtypes with K_i values ranging from 16.4 to greater than 3,000 nM in radioligand binding assays. LY334370 inhibits forskolin-induced cAMP accumulation in mouse L-M(TK-) cell membranes expressing the recombinant human 5-HT_1F receptor (EC₅₀ = 1.51 nM). It decreases electrically stimulated extravasation of plasma proteins in the dura mater in a guinea pig trigeminal nerve model of migraine headache.

Uses

LY 334370 Hydrochloride is a 5-HT1f receptor agoniist used potentially in the treatment of migranes.