199673-74-0

LY334370 is an agonist of the serotonin (5-HT) receptor subtype 5-HT_1F (K_d = 0.446 nM). It is selective for 5-HT_1F over other G protein-coupled 5-HT receptor subtypes with K_i values ranging from 16.4 to greater than 3,000 nM in radioligand binding assays. LY334370 inhibits forskolin-induced cAMP accumulation in mouse L-M(TK-) cell membranes expressing the recombinant human 5-HT_1F receptor (EC₅₀ = 1.51 nM). It decreases electrically stimulated extravasation of plasma proteins in the dura mater in a guinea pig trigeminal nerve model of migraine headache.

LY 334370 Hydrochloride is a 5-HT1f receptor agoniist used potentially in the treatment of migranes.

5-HT_1F Receptor: 0.446 nM (Kd)

Store at -20°C

[1] DAVID B WAINSCOTT. [3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 2005, 371 3: 169-177. DOI: 10.1007/s00210-005-1035-9
[2] K W JOHNSON. 5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs.[J]. Neuroreport, 1997, 8 9-10: 2237-2240. DOI: 10.1097/00001756-199707070-00029