Description
D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a key second messenger produced in cells by PLC-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate.1,2 Binding of Ins(1,4,5)P3 to one of several Ins(1,4,5)P3 receptors results in opening of the calcium channels and an increase in intracellular calcium.2,3 Ins(4,5)P2 is a metabolite of Ins(1,4,5)P3 that lacks a phosphate at the 1' position. Ins(4,5)P2 formation has been reported as an intermediate in the metabolism Ins(1,4,5)P3 in GH3 pituitary cells.4WARNING This product is not for human or veterinary use.
References
[1] H. STREB. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate[J]. Nature, 1983, 306 5938: 67-69. DOI:
10.1038/306067a0[2] Y YOSHIDA S I. Structure and function of inositol 1,4,5-trisphosphate receptor.[J]. Japanese journal of pharmacology, 1997, 74 2: 125-137. DOI:
10.1254/jjp.74.125[3] EXTON J H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins.[J]. Annual review of pharmacology and toxicology, 1996, 36: 481-509. DOI:
10.1146/annurev.pa.36.040196.002405[4] FERNANDA RUIZ-LARREA Alan H D. Pathways of dephosphorylation of 1-d-myo-inositol 1,4,5-trisphosphate in GH3 pituitary tumor cells[J]. Biochimica et biophysica acta. Molecular cell research, 1993, 1178 1: Pages 63-72. DOI:
10.1016/0167-4889(93)90110-b
