D-myo-Inositol-4,5-diphosphate (sodium salt)

D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a key second messenger produced in cells by PLC-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate.1,2 Binding of Ins(1,4,5)P3 to one of several Ins(1,4,5)P3 receptors results in opening of the calcium channels and an increase in intracellular calcium.2,3 Ins(4,5)P2 is a metabolite of Ins(1,4,5)P3 that lacks a phosphate at the 1' position. Ins(4,5)P2 formation has been reported as an intermediate in the metabolism Ins(1,4,5)P3 in GH3 pituitary cells.4WARNING This product is not for human or veterinary use.

[1] H. STREB. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate[J]. Nature, 1983, 306 5938: 67-69. DOI: 10.1038/306067a0
[2] Y YOSHIDA  S I. Structure and function of inositol 1,4,5-trisphosphate receptor.[J]. Japanese journal of pharmacology, 1997, 74 2: 125-137. DOI: 10.1254/jjp.74.125
[3] EXTON J H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins.[J]. Annual review of pharmacology and toxicology, 1996, 36: 481-509. DOI: 10.1146/annurev.pa.36.040196.002405
[4] FERNANDA RUIZ-LARREA  Alan H D. Pathways of dephosphorylation of 1-d-myo-inositol 1,4,5-trisphosphate in GH3 pituitary tumor cells[J]. Biochimica et biophysica acta. Molecular cell research, 1993, 1178 1: Pages 63-72. DOI: 10.1016/0167-4889(93)90110-b