Synthesis
General procedure for the synthesis of (R)-2,2,2-trifluoro-1-phenylethylamine from 1-phenyl-2,2,2-trifluoroethylamine:
1. Intermediate preparation: L-tartaric acid (36 g, 240.0 mmol) was added to a solution of 1-phenyl-2,2,2-trifluoroethylamine (40 g, 228.57 mmol) in isopropanol (400 mL).
2. Reaction: The reaction mixture was heated to reflux and maintained for 30 minutes.
3. Post-treatment: After completion of the reaction, the mixture was cooled to room temperature and the solid formed was collected by filtration.
4. Purification: The resulting solid was diluted with Na2CO3/H2O solution and subsequently extracted with dichloromethane (3 x 100 mL).
5. Drying and concentration: The organic phases were combined, dried over K2CO3 and subsequently concentrated under reduced pressure to afford the target product (1R)-2,2,2-trifluoro-1-phenylethylamine (12.5 g, 31% yield) as a white solid.
