Biological Activity
(±)-octanoylcarnitine chloride is a homolog of acetylcarnitine chloride. acylcarnitines, the acetyl derivatives of carnitine, are important intermediates in lipid metabolism, required for the transport of long-chain fatty acids into mitochondria for β-oxidation and atp production, and for the removal of excess short-chain and medium-chain fatty acids. (±)-octanoylcarnitine has been shown to decrease the oxidation rate of the branched-chain 2-oxo acids 4-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate in isolated rat muscle mitochondria in the presence of carnitine, but octanoyl-l-carnitine increases oxidation of 4-methyl-2-oxopentanoate in the absence of carnitine. in addition, (±)-octanoylcarnitine, along with malate, has been used as a mitochondrial respiration substrate to evaluate the effect of creatine on the respiration rate of isolated rat cardiac fibers exposed to increasing concentrations of adp.1. zhang y, ma q, bai x. effects of dietary acetyl-l-carnitine on meat quality and lipid metabolism in arbor acres broilers. asian-australasian journal of animal sciences, 2010, 23(12): 1639-1644.2. veerkamp jh, van moerkerk ht, wagenmakers aj. interaction of short-chain and branched-chain fatty acids and their carnitine and coa esters and of various metabolites and agents with branched-chain 2-oxo acid oxidation in rat muscle and liver mitochondria. international journal of biochemistry, 1985, 17(9): 967-974.3. toleikis a, trumbeckaite s, liobikas j, et al. fatty acid oxidation and mitochondrial morphology changes as key modulators of the affinity for adp in rat heart mitochondria. cells, 2020, 9(2): 340.
