Uses
Alatrioprilat is an orally active inhibitor of angiotensin-converting enzyme (ACE) (IC50=19.6 nM; Ki=9.8 nM) and enkephailnase (IC50=6.1 nM; Ki=5.1 nM). Alatrioprilat plays a key role in the metabolism of hormonal peptides through the degradation of nitric oxide and atrial natriuretic factor (ANF). Alatrioprilat can be used in the study of cardiovascular diseases[1].
References
[1] Gros C, et al. Mixed inhibitors of angiotensin-converting enzyme (EC 3.4. 15.1) and enkephalinase (EC 3.4. 24.11): rational design, properties, and potential cardiovascular applications of glycopril and alatriopril[J]. Proceedings of the National Academy of Sciences, 1991, 88(10): 4210-4214. DOI:
10.1073/pnas.88.10.4210
