Enzyme inhibitor
This substituted hydrazine (FWhydrochloride = 110.55 g/mol; CAS 79-17-4),
also named pimagedine, is a strong inhibitor of diamine oxidases as well as
nitric oxide synthase. Note that aminoguanidine also inhibits the formation
of advanced glycosylation end-products, reportedly by reacting with and
trapping Amadori rearrangement-derived fragmentation products in
solution. In view of this property, aminoguanidine has often been used to
treat complications associated with chronic diabetes. Target (s) : amine
oxidase (copper-containing), or diamine oxidase;
methylamine dehydrogenase; tryptophan tryptophylquinone enzymes
; nitric-oxide synthase; b-fructofuranosidase, or
invertase; monoamine oxidase, or amine oxidase; histidine
decarboxylase; aldose reductase; catalase; formation of
advanced glycosylation end products; adenosylmethionine
decarboxylase; arginine deaminase; arginine kinase;
aspartate aminotransferase; histamine N-methyltransferase.
