4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]morpholine

Uses

4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)morpholine is a synthetic chemical that is used in industrial synthesis. It can be used in the production of pharmaceuticals, plastics, pesticides, and herbicides.

Hazard

4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZYL]MORPHOLINE is harmful if swallowed and may cause severe eye and skin irritation on contact. Inhalation may cause respiratory irritation. Use with caution.

Synthesis

4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)morpholine can be synthesized from bromobenzoate and pinacol in high yield under mild reaction conditions.

References

[1] Patent: WO2009/155565, 2009, A1. Location in patent: Page/Page column 143-144
[2] Patent: WO2013/153357, 2013, A1. Location in patent: Page/Page column 18; 39; 40
[3] Patent: US2015/45354, 2015, A1. Location in patent: Paragraph 0237-0241
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 20, p. 2989 - 2992
[5] Journal of Medicinal Chemistry, 2008, vol. 51, # 2, p. 196 - 218