Description
Obscurolide A
1 is a natural butyrolactone isolated from S. viridochromogenes.
1 It inhibits calcium/calmodulin-
dependent phosphodiesterase from bovine brain, presumably PDE1 (IC
50 = 15 mM).
1
References
1. Hoff, H., Drautz, H., Fiedler, H.P., et al.
Metabolic products of microorganisms. 261. Obscurolides, a novel class of phosphodiesterase inhibitors from streptomyces. I. Production, isolation, structural elucidation and biological activity of obscurolides A1 to A4 J. Antibiot. (Tokyo) 45(7),1096-1107(1992).
