144397-99-9

Obscurolide A₁ is a natural butyrolactone isolated from S. viridochromogenes.¹ It inhibits calcium/calmodulin-dependent phosphodiesterase from bovine brain, presumably PDE1 (IC₅₀ = 15 mM).¹

Obscurolide A1 is a Phosphodiesterase (PDE) inhibitor (IC50=8 mM) that can be obtained from Streptomyces viridochromogenes culture. Obscurolide A1 has the potential to study neurological and inflammatory diseases[1].

ChEBI: Obscurolide A1 is an aminobenzoic acid.

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1. Hoff, H., Drautz, H., Fiedler, H.P., et al. Metabolic products of microorganisms. 261. Obscurolides, a novel class of phosphodiesterase inhibitors from streptomyces. I. Production, isolation, structural elucidation and biological activity of obscurolides A₁ to A₄ J. Antibiot. (Tokyo) 45(7),1096-1107(1992).