Uses
3-Nitrosothiazolidine is a nitrosamine present in food products, a carcinogenic substance.
Definition
ChEBI: N-nitroso-1,3-thiazolidine is a nitrosamine and a member of thiazolidines.
Safety Profile
Moderately toxic by ingestion. Mutation data reported. Many N-nitroso compounds are carcinogens. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Metabolic pathway
N-Nitroso-1,3-thiazolidine administered by gavage to
rats is excreted mostly in the urine with a small
amount in respired air. The major metabolite in the
urine is 2-hydroxy-1,3-thiazolidine, and minor
quantities of the isomers 4- and 5-hydroxy-1,3-
thiazolidines are detected. The presence of
hydroxy-1,3-thiazolidine indicates that a-hydroxylation
and denitrosation are major metabolic pathways of
N-nitroso-1,3-thiazolidine.
