Description
Leustroducsin B is a novel colony-stimulating factor (CSF) inducer isolated from Streptomyces platensis SANK 60191.
Uses
Leustroducsin B is a colony-stimulating factor (CSF) inducer. Leustroducsin B induces CSF production in bone marrow stromal cells[1].
in vivo
Leustroducsin B (0.1-0.3 mg/kg; ip; once daily; for three to six days) induces thrombocytosis in mice[1].
| Animal Model: | Pathogen-free C57BL/6 male mice (Seven-week-old)[1] |
| Dosage: | 0.1 mg/kg; 0.3 mg/kg |
| Administration: | ip; once daily; for three to six days |
| Result: | Induced thrombocytosis in mice.
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References
[1] T Kohama, et al. Leustroduscin B, a new cytokine inducer derived from an actinomycetes, induces thrombocytosis in mice. J Antibiot (Tokyo). 1996 Jan;49(1):91-4. DOI:
10.7164/antibiotics.49.91
