MKT 077

Description

MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC₅₀s = 1.4-2.2 μM in vitro) through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. It has been shown to bind to an allosteric site conserved in Hsp70 family members, interfering with ATP hydrolysis and abrogating the interaction of the chaperone with the tumor suppressor p53.

Uses

MKT-077 is used in the treatment of Alzheimer’s diseases and other tauopathie’s. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance

Biochem/physiol Actions

MKT-077 is an inhibitor of mitochondrial hsp70 family member, mortalin (mot-2)n; causes selective death of cancer cells.

storage

Store at +4°C